By Janet D. Rowley,Michelle M. Le Beau,Terence H. Rabbitts
This quantity collates international specialists’ insights into the molecular biology of melanoma chromosomes, their abnormalities and the next mobile outcomes. Exploring topics related to oncogenes, equivalent to by means of chromosomal translocations, different genome rearrangements and somatic mutations, this e-book is a overview of the sphere of melanoma genetics that presages a brand new period, as entire genome sequencing turns into extra accessible.
The paintings starts off with a glance at ancient topics, equivalent to the research of metaphase chromosomes utilizing microscopy and marking innovations, advances within which supplied our first vast glimpse into the genetic anatomy of a malignant telephone. Readers will find out about the applying of DNA molecular cloning recommendations within the Nineteen Eighties, that ended in the identity of the genes desirous about the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the function of oncogenes and tumour suppressor genes in melanoma aetiology through chromosomal changes and which introduced a box in melanoma genetics.
Subsequent chapters carry the reader brand new through reviewing fresh advancements within the box, with committed sections on leukaemia/lymphoma, sarcomas and epithelial tumours.
Contributions characteristic a number of color tables and illustrations and this quantity will supply a foundation for figuring out melanoma chromosomes for a few years to come.
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Extra resources for Chromosomal Translocations and Genome Rearrangements in Cancer
Chromosomal Translocations and Genome Rearrangements in Cancer by Janet D. Rowley,Michelle M. Le Beau,Terence H. Rabbitts